Groups

Spontaneous locomotor activity (SLA) parameters

Locomotors activity

Stereotype movements

υ_max cm/s

υ_mean cm/s

Distance, cm

Time of rest, %

Slow movements, %

Fast movements, %

Number of rearings

Non-defeated mice

Vehicle- control mice

477.2 ± 35.9

100.0

(47.0/163.0)

28.9

(17.6/38.5)

3.9 ± 0.8

673.9

(388.4/958.7)

48.4 ± 3.7

35.7 ± 4.3

12.8

(6.9/24.4)

47.0

(37.0/59.0)

Ladasten 30 mg/kg, i.p.

387.7 ± 34.1

64.5

(44.0/92.0)

14.9

(14.0/16.3)

2.7 ± 1.2

290.7^*

(208.0/345.4)

64.9 ± 3.1^*

37.6 ± 3.2

10.2

(6.0/14.6)

19.5

(13.0/28.0)

30 days of SDS mice

Vehicle

366.4 ± 43.1^*

43.5^*

(24.0/56.0)

12.3^*

(10.5/17.5)

2.3 ± 0.7

238.5^*

(173.9/421.6)

62.5 ± 4.7^*

34.1 ± 4.6

3.2^*

(1.9/5.1)

29.5

(23.0/38.0)

Ladasten, 30 mg/kg, i.p.

421.8 ± 39.2

60.5

(57.0/69.0)

19.7

(16.3/37.3)

5.6 ± 1.6

383.5

(37.3/477.8)

54.5 ± 4.3

34.7 ± 4.4

5.5

(4.0/13.2)

49.0

(28.0/58.0)